What it is: Boluoke® is a single-ingredient, research-based oral lumbrokinase enzyme supplement from Canada RNA Biochemical, delivering 600,000 IU (26 mg, 1.6 million tPA activities) of standardized Lumbrokinase per serving in acid-resistant capsules designed to resist gastric acid and dissolve in the small intestine for maximum enzymatic bioavailability. Lumbrokinase is a multi-fraction serine protease enzyme complex extracted and purified from earthworm (Lumbricus rubellus), with over 30 years of clinical use and multiple clinical trials supporting its safety and efficacy profile since 1992. Boluoke® is the only lumbrokinase product standardized to no less than 12,000 lumbrokinase units per milligram and independently lab-tested to no less than 1.6 million tPA units per capsule.
How it works: Lumbrokinase supports circulatory health through a distinct multi-enzyme fibrinolytic mechanism. Unlike nattokinase or systemic proteolytic enzymes, lumbrokinase acts on multiple points of the coagulation and fibrinolytic cascade — directly degrading fibrin clot structure, activating endogenous tissue plasminogen activator (tPA), inhibiting plasminogen activator inhibitor-1 (PAI-1), and modulating platelet aggregation — supporting a healthy fibrinolytic balance and blood fluidity within normal physiological parameters. Because Boluoke® does not significantly affect prothrombin time (PT) or activated partial thromboplastin time (aPTT), it does not meaningfully alter INR — distinguishing it from anticoagulant medications and from other lumbrokinase preparations, which may significantly affect PT or aPTT depending on their extraction method and enzyme sub-fraction composition.
When to use it: Indicated for adults requiring circulatory health support, fibrinolytic balance, and healthy blood viscosity — particularly in protocols addressing hypercoagulation, poor peripheral circulation, cardiovascular inflammatory burden, or post-infectious circulatory sequelae. One to two capsules one to three times daily on an empty stomach. Discontinue at least one week prior to surgery and resume no earlier than 15 days post-surgery. Use with caution alongside anticoagulant, antiplatelet, or NSAID medications under appropriate clinical monitoring. Contraindicated in clients with active bleeding, GI ulceration, high-risk aneurysm, recent trauma, or known allergy to earthworm-derived products.
Serving Size: 2 Capsules
Servings Per Container: 15
Suggested Use: As a dietary supplement, take 1–2 capsules one to three times daily on an empty stomach, or as directed by your healthcare practitioner.
| Ingredient | Amount Per Serving | % Daily Value |
|---|---|---|
| Lumbrokinase (600,000 IU) (1.6 million tPA activities) | 26 mg | † |
† Daily Value not established.
Other Ingredients: Acid-resistant hydroxypropyl methylcellulose, microcrystalline cellulose.
Caution: Consult your healthcare practitioner before use if you are pregnant, breastfeeding, taking an anticoagulant, antiplatelet agent (including aspirin, Plavix, or Ticlid), or any other prescription medication. Do not use if you have an allergy to earthworms or earthworm-derived products, or a known bleeding tendency. Contraindicated in active internal bleeding, GI ulceration, high-risk aneurysm, recent surgery, pre-surgery, lumbar or arterial puncture, trauma, or any other bleeding disorder. Discontinue at least 1 week prior to surgery. Do not take concurrently with other proteolytic enzyme products without practitioner guidance. Keep out of reach of children. Store at room temperature away from moisture, direct sunlight, and excessive heat. Do not use if the safety seal is broken or missing.
✓ Gluten Free ✓ Dairy Free ✓ Soy Free ✓ Egg Free ✓ Corn Free ✓ Nut Free ✓ No Artificial Colors, Flavors, or Preservatives
Key Ingredients:
Lumbrokinase (600,000 IU, 1.6 million tPA activities) — 26 mg per serving Boluoke® Lumbrokinase is a multi-fraction serine protease enzyme complex extracted and purified from Lumbricus rubellus (earthworm), standardized to no less than 12,000 lumbrokinase units per milligram and independently lab-verified to no less than 1.6 million tPA activities per capsule — the most rigorously quality-controlled lumbrokinase preparation commercially available, with a clinical safety and efficacy profile spanning over 30 years and multiple hospital-based clinical trials. Lumbrokinase supports fibrinolytic balance through simultaneous activity at multiple points of the coagulation cascade — directly degrading fibrin, activating endogenous tPA, inhibiting PAI-1, and modulating platelet aggregation — without significantly altering PT, aPTT, or INR, a key pharmacological distinction from anticoagulant medications and from other lumbrokinase preparations whose different extraction methods produce different enzyme sub-fraction profiles that can significantly affect clotting times. At 26 mg per serving (600,000 IU, 1.6 million tPA activities) delivered in acid-resistant hydroxypropyl methylcellulose capsules that protect enzymatic activity through the stomach and dissolve in the small intestine, Boluoke® provides the clinical-grade fibrinolytic enzyme support required for protocols addressing hypercoagulation, poor peripheral circulation, cardiovascular inflammatory burden, and post-infectious circulatory sequelae.
