What it is: Alpha GABA PM is a five-ingredient sleep and relaxation formula from NeuroScience combining 400 mg of L-theanine and 3 mg of melatonin with a 530 mg proprietary botanical blend of micro-encapsulated Valerian root extract (0.8% Valerenic acids), whole Lemon balm leaf extract, and 5-HTP from Griffonia simplicifolia. Formulated to support GABAergic and serotonergic calming, alpha brain wave induction, and sleep-wake cycle regulation. Third-party tested for label accuracy and free from heavy metals, pesticides, and microbial contaminants.
How it works: L-theanine (400 mg) is the formula's primary active — at this high-concentration dose, L-theanine acts as a glutamate receptor antagonist, reducing excitatory neurotransmission while promoting alpha brain wave generation — the EEG signature of calm, relaxed wakefulness that precedes healthy sleep onset. Research demonstrates that L-theanine at 250 mg or above significantly lowers glutamate activity and reduces subjective stress, with alpha wave induction confirmed in both stressed and non-stressed individuals. Melatonin (3 mg) supports circadian sleep-wake cycle regulation and has been shown to rapidly increase alpha brain waves alongside L-theanine's mechanism — together accelerating the neurological transition from alertness to sleep. Valerian root extract (0.8% Valerenic acids, micro-encapsulated to reduce botanical odor) modulates GABA-A receptors through Valerenic acid-mediated allosteric enhancement — reducing neural excitability and supporting sleep onset. Lemon balm leaf extract (proprietary whole extract) inhibits GABA transaminase — the enzyme that degrades GABA — supporting GABAergic tone and contributing anxiolytic and calming activity. 5-HTP from Griffonia simplicifolia provides serotonin precursor support — the serotonin pathway being central to both mood regulation and melatonin biosynthesis, linking 5-HTP's activity to the formula's broader sleep architecture support.
When to use it: Indicated for adults with difficulty initiating or maintaining sleep — particularly stress-driven insomnia, racing mind at bedtime, and anxiety-associated sleep disruption. One to two capsules at bedtime. Do not exceed suggested use. Not recommended during pregnancy or breastfeeding without healthcare practitioner guidance. May be combined with other NeuroScience neurotransmitter support formulas under practitioner direction.
Serving Size: 2 Capsules
Servings Per Container: 30
Suggested Use: As a dietary supplement, take 1–2 capsules at bedtime, or as directed by your healthcare practitioner. Do not exceed suggested use.
| Ingredient | Amount Per Serving | % Daily Value |
|---|---|---|
| L-theanine | 400 mg | † |
| Melatonin | 3 mg | † |
| Proprietary Blend (Valerian (Valeriana officinalis) root extract (0.8% Valerenic acids) (micro-encapsulated), Lemon balm (Melissa officinalis) leaf extract, 5-Hydroxytryptophan (from Griffonia simplicifolia seed extract)) | 530 mg | † |
† Daily Value not established.
Other Ingredients: Vegetable capsule (hypromellose, water), organic rice concentrate, silica.
Caution: Do not exceed suggested use. If pregnant or nursing, consult your healthcare practitioner before use. This product contains a tamper-evident seal under the cap — do not use if seal is broken or missing. Keep out of reach of children. Store at room temperature in a dry place.
✓ Vegetarian ✓ Gluten Free ✓ Non-GMO ✓ Third-Party Tested ✓ No Artificial Colors or Flavors
Key Ingredients:
L-theanine — 400 mg L-theanine is a non-protein amino acid found naturally in green tea, delivered here at 400 mg per serving — a high-concentration dose shown in published research to significantly induce alpha brain waves, the neurological signature of calm, relaxed wakefulness. At doses of 250 mg and above, L-theanine acts as a glutamate receptor antagonist — blocking the attachment of glutamate at NMDA and AMPA receptors and lowering excitatory neurotransmission — while simultaneously supporting GABA synthesis to promote inhibitory nervous system tone. At 400 mg, L-theanine provides the formula's primary evidence-based mechanism for calming a stress-activated, racing mind at bedtime — supporting the alpha wave state that precedes healthy sleep onset through a non-sedating, non-dependency-forming mechanism.
Melatonin — 3 mg Melatonin is the pineal-derived hormone central to circadian sleep-wake cycle regulation, delivered at the research-supported 3 mg dose that has been shown to improve sleep onset latency and sleep quality without the morning grogginess associated with higher doses. Research has additionally demonstrated that melatonin supplementation rapidly increases alpha brain waves — directly amplifying L-theanine's primary alpha wave-inducing mechanism and creating a synergistic neurological calming effect within this formulation. At 3 mg per serving, melatonin supports the neuroendocrine signaling of nighttime onset, promotes circadian rhythm entrainment, and contributes to the GABAergic inhibitory tone that supports sleep maintenance alongside the botanical blend.
Proprietary Blend — 530 mg (Valerian, Lemon Balm, 5-HTP) The 530 mg Proprietary Blend combines three clinically recognized sleep and calming botanicals operating through complementary GABAergic, serotonergic, and HPA axis mechanisms. Valerian root extract (0.8% Valerenic acids, micro-encapsulated for improved palatability) modulates GABA-A receptors through Valerenic acid allosteric enhancement — reducing neural excitability and supporting sleep onset through a mechanism comparable to benzodiazepine receptor modulation but without dependency risk. Lemon balm (Melissa officinalis) whole leaf extract inhibits GABA transaminase — the enzyme that catabolizes GABA — elevating endogenous GABAergic tone and contributing well-documented anxiolytic and sleep-promoting activity. 5-HTP from Griffonia simplicifolia provides the immediate serotonin biosynthesis precursor that supports serotonin production for mood stabilization and serves as the upstream substrate for melatonin synthesis — linking serotonergic replenishment directly to enhanced sleep architecture and circadian hormone support.
