What it is: Transformation Enzymes Protease is a high-potency single-ingredient systemic proteolytic enzyme formula delivering 355,000 HUT of TZyme™ Protease Blend activity per capsule — the brand's strongest systemic protease formulation — in a vegetable capsule with calcium citrate for improved gastric tolerance. The TZyme™ Protease Blend combines broad-spectrum endo- and exopeptidases with Bromelain, active across a pH range of 3.0–10.0 for consistent enzymatic activity throughout the full GI tract. Third-party tested, vegetarian, and manufactured in the USA.
How it works: Systemic proteolytic enzymes taken on an empty stomach are absorbed intact through the intestinal mucosa and distributed systemically — where they support fibrin degradation, immune complex clearance, lymphatic drainage, and tissue repair beyond the digestive tract. The TZyme™ Protease Blend delivers over 355,000 HUT of combined endo- and exopeptidase activity across the broadest pH range available — ensuring enzymatic activity from the acidic gastric environment through the alkaline small intestine. Endopeptidases cleave internal peptide bonds of protein chains while exopeptidases cleave terminal amino acids — together providing more complete and efficient protein hydrolysis than single-type proteases. Bromelain (19 SAPU) contributes additional plant-derived proteolytic activity with documented anti-inflammatory and fibrinolytic properties. When taken with meals, the same enzymes support dietary protein digestion and amino acid absorption — making this formula dual-purpose for both systemic and digestive applications.
When to use it: Indicated for adults requiring systemic proteolytic enzyme support for healthy circulation, lymphatic drainage, immune complex clearance, natural elimination, and tissue repair — or targeted protein digestion support with meals. One capsule twice daily on an empty stomach with 8 oz. of water for systemic use; one capsule with meals for digestive protein support. Dose may be increased per clinical direction. Contraindicated in active bleeding disorders. Use with caution alongside anticoagulant or antiplatelet medications. Consult a healthcare practitioner before use if pregnant, nursing, or managing a medical condition.
Serving Size: 1 Capsule
Servings Per Container: 120
Suggested Use: As a dietary supplement, take 1 capsule twice daily on an empty stomach with 8 oz. of water, or as directed by your healthcare practitioner. May also be taken with meals to enhance dietary protein digestion. Contents may be removed from capsule and taken by spoon immediately after mixing with a small amount of tepid water.
| Ingredient | Amount Per Serving | % Daily Value |
|---|---|---|
| TZyme™ Protease Blend (peptidases, bromelain) (355,020 HUT + 19 SAPU) (600,000 PU) | 492 mg | † |
† Daily Value not established.
Other Ingredients: Vegetable capsule (hypromellose, water), calcium citrate.
Caution: If pregnant, nursing, have a medical condition, or are taking medications — particularly anticoagulant or antiplatelet agents — consult your healthcare practitioner before use. Do not use if you have an active bleeding disorder. Discontinue use if adverse reactions occur. Keep out of reach of children. Store tightly sealed in a cool, dry place.
✓ Vegetarian ✓ Non-GMO ✓ Third-Party Tested ✓ Manufactured in the USA
Key Ingredients:
TZyme™ Protease Blend (peptidases, bromelain) — 492 mg (355,020 HUT + 19 SAPU, 600,000 PU) TZyme™ is Transformation Enzymes' proprietary proteolytic enzyme blend — combining a broad-spectrum endo- and exopeptidase matrix with Bromelain, formulated for pH stability across the full 3.0–10.0 range and standardized to 355,020 HUT (hemoglobin units on a tyrosine basis) of protease activity per capsule. Endopeptidases cleave internal peptide bonds within protein chains while exopeptidases cleave terminal amino acids — together delivering more complete protein hydrolysis than single-type protease formulations — and when absorbed systemically on an empty stomach, support fibrin degradation, immune complex clearance, lymphatic drainage, and transport of immune cells throughout the body. Bromelain (19 SAPU), the plant-derived cysteine protease from pineapple stem, contributes additional proteolytic activity with documented anti-inflammatory and fibrinolytic properties — extending the formula's systemic anti-inflammatory coverage beyond the serine protease activity of the peptidase matrix.
