What it is: Tran)Qwill™ is a nine-ingredient botanical formula from Panaxea International formulated to support nervous system calming, serotonergic balance, and cognitive focus in adults with anxiety and stress-driven hyperreactivity. Key actives include Griffonia simplicifolia standardized to 5-HTP and Ramulus cum uncis Uncariae standardized to 10% alkaloid. Manufactured to Australian Pharmaceutical GMP standards for exclusive practitioner-directed use.
How it works: 5-HTP crosses the blood-brain barrier directly to support serotonin synthesis — addressing the neurochemical deficit underlying anxiety and mood disturbance. Uncaria hook alkaloids modulate dopamine, 5-HT1A, and NMDA receptors, reducing nervous system hyperreactivity, anxiety-driven hypertension, and headache. Patrinia scabiosaefolia delivers sedative, hypnotic, and anti-neuroinflammatory activity. Radix Ginseng standardized to Ginsenoside Rb supports memory, attention, and HPA axis regulation without stimulant effect. Biota seed modulates GABA and serotonin pathways to support sleep onset and cardiac calm. Mimosa pudica contributes GABAergic and serotonergic CNS-calming activity. Spina Acanthopanacis provides adaptogenic stress resistance and immune support.
When to use it: Indicated for adults with anxiety, nervous system hyperreactivity, poor concentration, emotional dysregulation, or stress-related fatigue. Two to four capsules daily. Contraindicated with SSRIs, SNRIs, or MAOIs without practitioner oversight. Not recommended during pregnancy or breastfeeding. May cause drowsiness — advise clients to avoid operating heavy machinery.
Serving Size: 2 Capsules
Servings Per Container: 30
Suggested Use: As a dietary supplement, take 2–4 capsules daily, or as prescribed by your healthcare practitioner.
|
Ingredient |
Amount Per Serving |
% Daily Value |
|
Griffonia simplicifolia (contains: standardized 5-Hydroxytryptophan) |
50 mg |
† |
|
Mimosa Pudica |
100 mg |
† |
|
Cortex Albizziae Julibrissin (He Huan Pi / Silk Tree Bark) |
30 mg |
† |
|
Radix Ginseng (contains: standardized Ginsenoside Rb) |
55 mg |
† |
|
Spina Acanthopanacis |
150 mg |
† |
|
Semen Astragali Complanati (Sha Yuan Ji Li) |
150 mg |
† |
|
Semen Biotae Orientalis (Bai Zi Ren / Oriental Arborvitae Seed) |
145 mg |
† |
|
Patrinia scabiosifolia |
160 mg |
† |
|
Ramulus cum uncis Uncariae (Gou Teng / Uncaria Hook) (standardized to 10% alkaloid) |
160 mg |
† |
† Daily Value not established.
Other Ingredients: Vegetable cellulose (hypromellose), vegetable stearic acid, microcrystalline cellulose, vegetable magnesium stearate.
Does Not Contain: Wheat, gluten, soy, milk, eggs, fish, crustacean shellfish, tree nuts, peanuts.
Caution: If pregnant, nursing, or taking medications — particularly SSRIs, SNRIs, or MAOIs — consult your healthcare practitioner before use due to the 5-HTP serotonergic content. Do not use if you have known hypersensitivity to any of the ingredients. Do not use if tamper-evident seal is broken or missing. Keep out of reach of children. Store in a cool, dry place away from sunlight.
✓ Vegetarian ✓ Gluten Free ✓ Dairy Free ✓ Soy Free ✓ Egg Free ✓ Nut Free ✓ Australian Pharmaceutical GMP Manufactured
Key Ingredients
Griffonia simplicifolia (standardized to 5-Hydroxytryptophan) — 50 mg Griffonia simplicifolia seed is standardized to 5-HTP — the immediate serotonin precursor with direct blood-brain barrier permeability, bypassing the conversion rate limitations of dietary L-tryptophan. Multiple clinical trials support its capacity to reduce anxiety severity, improve mood, and support sleep through serotonin-to-melatonin conversion. It provides the formula's foundational serotonergic mechanism upon which the formula's botanical complement operates.
Ramulus cum uncis Uncariae (Uncaria Hook, standardized to 10% alkaloid) — 160 mg Uncaria hook is standardized to 10% total alkaloid — delivering rhynchophylline, isorhynchophylline, and geissoschizine methyl ether with documented antihypertensive, sedative, anti-neuroinflammatory, and neuroprotective activity. These alkaloids act as calcium channel modulators, dopamine receptor modulators, partial 5-HT1A agonists, and NMDA receptor antagonists. At the formula's highest dose, they directly address the cardiovascular and neurological manifestations of anxiety-driven hyperreactivity — including hypertension, headache, dizziness, and agitation.
Patrinia scabiosaefolia — 160 mg Patrinia scabiosaefolia delivers triterpenoid saponins, iridoid glycosides, and volatile compounds with documented sedative, hypnotic, and CNS-depressant activity in both preclinical and clinical research. It reduces CNS excitability, promotes sleep onset, and reduces neuroinflammatory burden — complementing Uncaria's alkaloid-mediated neuromodulation through a distinct botanical mechanism. At 160 mg, it matches Uncaria as the formula's joint highest-dose ingredient.
Radix Ginseng (standardized to Ginsenoside Rb) — 55 mg Radix Ginseng is standardized to Ginsenoside Rb — the ginsenoside group associated with neuroprotective, memory-supporting, and HPA axis-regulatory activity, without the stimulant profile of Rg-type ginsenosides. Rb1 and Rb2 support hippocampal neuroplasticity, BDNF expression, and acetylcholinesterase regulation. This provides the formula's targeted cognitive recovery activity for clients whose anxiety presentation includes concentration deficits and mental fatigue.
Spina Acanthopanacis — 150 mg Spina Acanthopanacis (Eleutherococcus senticosus) delivers eleutherosides and lignans with documented capacity to support physical and mental stress resistance, immune modulation, and cognitive performance under chronic demand. Its adaptogenic activity normalizes stress hormone dysregulation and supports mitochondrial energy production. At 150 mg it provides the formula's primary stress-resistance and physical resilience activity — addressing the energy depletion that co-occurs with chronic anxiety.
